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. 2012 May 14;197(4):509–521. doi: 10.1083/jcb.201201057

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© 2012 Wei et al.

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Figure 7. — miR-34b and -c regulate bone mass accrual in a Satb2-dependent manner. (A) SATB2 protein level in bones of miR-34bc^Osb−/−;Satb2^+/− mice (n = 3–10 of each genotype). (B) Histomorphometric analysis of L3 and L4 vertebrae of miR-34bc^Osb−/−;Satb2^+/− mice (n = 7–12) at 3 mo of age. Representative histological images were shown. Bar, 20 µm. (C) Expression level of Osteocalcin and Bsp in bones of miR-34bc^Osb−/−;Satb2^+/− mice (n = 5–9), determined by qPCR. Asterisks in A, B, and C indicate that miR-34bc^Osb−/− mice are significantly different from the other groups; P ≤ 0.05. Error bars indicate means ± standard errors of the mean. (D) Model of the functions of miR-34s in osteoblasts.