Table 3. Determinants of dexmedetomidine clearance in ICU patients.

The table presents posterior means and 95 % credible intervals for the parameters from the Bayesian hierarchical nonlinear mixture model

Parameter	Posterior mean	95 % credible interval
Smoking	0.147	−0.246 to 0.545
Weight	0.008	−0.0003 to 0.016
Age	−0.002	−0.017 to 0.012
Genotype (SM vs NM)	0.321	−0.690 to 1.348
Genotype (IM vs NM)	0.139	−0.473 to 0.779

The following equation takes into account the posterior means and was used to determine the subject-specific clearance.

Cl_i = 0.147×Smoking + 0.008×Weight – 0.002×Age + 0.321×SM + 0.139×IM, where Cl_i is subject specific clearance, Smoking is an indicator for smoking status (Smoking = 1 if a subject is smoker, and Smoking = 0 for nonsmoker), Weight is body weight in kg, Age is age in years, SM is an indicator for slow metabolizer (SM=1 if a subject is slow metabolizer, and SM = 0 otherwise) and IM is an indicator for intermediate metabolizer (IM = 1 if a subject is intermediate metabolizer, and IM = 0 otherwise).