Table 2. Short lists of DEGs in psoriasis lesional EPI vs. non-lesional EPI (LCM)*.
| a. Top 25 Up-regulated genes in psoriasis lesional EPI vs. non-lesional EPI | ||||||
|---|---|---|---|---|---|---|
| Probe Set ID | Symbol | EPI (LCM) | Bulk | Description | ||
| FCH | FDR | FCH | FDR | |||
| 211906_s_at | SERPINB4 | 470.72 | <0.01 | 419.60 | <0.01 | serpin peptidase inhibitor, clade B member 4 |
| 209720_s_at | SERPINB3 | 366.10 | <0.01 | 171.61 | <0.01 | serpin peptidase inhibitor, clade B member 3 |
| 203535_at | S100A9 | 136.52 | <0.01 | 106.56 | <0.01 | S100 calcium binding protein A9 |
| 203691_at | PI3 | 128.03 | <0.01 | 67.67 | <0.01 | peptidase inhibitor 3, skin-derived |
| 207356_at | DEFB4 | 114.24 | <0.01 | 69.88 | <0.01 | defensin, beta 4 |
| 205916_at | S100A7 | 84.37 | <0.01 | 10.67 | 0.21 | S100 calcium binding protein A7 (psoriasin) |
| 213680_at | KRT6B | 67.99 | <0.01 | 3.61 | 0.54 | keratin 6B |
| 205863_at | S100A12 | 57.07 | <0.01 | 32.81 | <0.01 | S100 calcium binding protein A12 |
| 209125_at | KRT6A | 55.71 | <0.01 | 18.77 | 0.02 | keratin 6A |
| 217272_s_at | SERPINB13 | 55.50 | <0.01 | 8.13 | <0.01 | serpin peptidase inhibitor, clade B member 13 |
| 220322_at | IL1F9 | 55.34 | <0.01 | 19.15 | <0.01 | interleukin 1 family, member 9 (IL-36 gamma) |
| 206488_s_at | CD36 | 53.72 | <0.01 | 1.80 | 0.30 | CD36 molecule |
| 202917_s_at | S100A8 | 50.84 | 0.03 | 53.07 | 0.14 | S100 calcium binding protein A8 |
| 205513_at | TCN1 | 50.11 | <0.01 | 39.15 | <0.01 | transcobalamin I |
| 219795_at | SLC6A14 | 47.10 | <0.01 | 5.84 | 0.13 | solute carrier family 6 member 14 |
| 206177_s_at | ARG1 | 46.24 | <0.01 | 3.57 | 0.07 | arginase, liver |
| 220664_at | SPRR2C | 45.97 | <0.01 | 32.99 | <0.01 | small proline-rich protein 2C |
| 213796_at | SPRR1A | 35.17 | <0.01 | 6.03 | 0.24 | small proline-rich protein 1A |
| 208650_s_at | CD24 | 29.72 | <0.01 | 7.49 | <0.01 | CD24 molecule |
| 206643_at | HAL | 24.28 | <0.01 | 5.42 | <0.01 | histidine ammonia-lyase |
| 207381_at | ALOX12B | 22.66 | <0.01 | 4.59 | <0.01 | arachidonate 12-lipoxygenase, 12R type |
| 209800_at | KRT16 | 21.75 | <0.01 | 16.48 | 0.02 | keratin 16 |
| 201242_s_at | ATP1B1 | 21.33 | <0.01 | 2.46 | 0.57 | ATPase, Na+/K+ transporting, β 1 polypeptide |
| 206561_s_at | AKR1B10 | 20.04 | <0.01 | 20.14 | <0.01 | aldo-keto reductase family 1, member B10 |
| 213060_s_at | CHI3L2 | 19.97 | <0.01 | 5.46 | <0.01 | chitinase 3-like 2 |
| b. Top 25 Down-regulated genes in psoriasis lesional EPI vs. non-lesional EPI | ||||||
|---|---|---|---|---|---|---|
| Probe Set ID | Symbol | EPI (LCM) | Bulk | Description | ||
| FCH | FDR | FCH | FDR | |||
| 210809_s_at | POSTN | -62.50 | <0.01 | -1.44 | 0.35 | periostin, osteoblast specific factor |
| 205081_at | CRIP1 | -20.41 | <0.01 | -2.48 | 0.17 | cysteine-rich protein 1 (intestinal) |
| 214598_at | CLDN8 | -15.38 | <0.01 | -4.57 | 0.08 | claudin 8 |
| 201540_at | FHL1 | -9.80 | <0.01 | -1.88 | 0.35 | four and a half LIM domains 1 |
| 219087_at | ASPN | -9.52 | <0.01 | -1.79 | 0.50 | asporin |
| 215516_at | LAMB4 | -9.17 | <0.01 | -1.98 | <0.01 | laminin, beta 4 |
| 201843_s_at | EFEMP1 | -8.85 | <0.01 | -1.89 | 0.22 | EGFcontaining fibulin-like extracellular matrix protein1 |
| 213369_at | PCDH21 | -8.26 | <0.01 | -2.26 | 0.07 | protocadherin 21 |
| 202746_at | ITM2A | -7.87 | <0.01 | -2.35 | 0.03 | integral membrane protein 2A |
| 206170_at | ADRB2 | -7.52 | <0.01 | -2.95 | 0.01 | adrenergic, beta-2-, receptor, surface |
| 209292_at | ID4 | -7.41 | <0.01 | -3.06 | 0.06 | inhibitor of DNA binding 4 |
| 207955_at | CCL27 | -7.25 | 0.01 | -3.38 | 0.21 | chemokine (C-C motif) ligand 27 |
| 202973_x_at | FAM13A | -7.25 | <0.01 | -1.76 | 0.07 | family with sequence similarity 13, member A |
| 201506_at | TGFBI | -7.04 | <0.01 | -1.72 | 0.13 | transforming growth factor, β-induced, 68kDa |
| 215239_x_at | ZNF273 | -6.85 | <0.01 | -2.29 | 0.28 | zinc finger protein 273 |
| 218804_at | ANO1 | -6.80 | <0.01 | -1.58 | 0.57 | anoctamin 1 |
| 208096_s_at | COL21A1 | -6.71 | <0.01 | -1.85 | 0.14 | collagen, type XXI, α 1 |
| 218820_at | C14orf132 | -6.62 | <0.01 | -2.47 | 0.12 | chromosome 14 open reading frame 132 |
| 217627_at | ZNF573 | -6.25 | <0.01 | -2.41 | 0.13 | zinc finger protein 573 |
| 209335_at | DCN | -6.21 | <0.01 | -1.54 | 0.26 | decorin |
| 221645_s_at | ZNF83 | -5.65 | <0.01 | -1.78 | 0.12 | zinc finger protein 83 |
| 214723_x_at | ANKRD36 | -5.49 | <0.01 | -1.53 | 0.58 | ankyrin repeat domain 36 |
| 220940_at | ANKRD36B | -5.49 | <0.01 | -1.54 | 0.49 | ankyrin repeat domain 36B |
| 203881_s_at | DMD | -5.46 | 0.02 | -2.10 | 0.54 | dystrophin |
| 206030_at | ASPA | -5.41 | <0.01 | -1.51 | 0.74 | aspartoacylase |
*
The Probe Set ID whose fold change was largest was listed when multiple probe sets were available for same gene. Un-annotated genes were excluded from the top 25 gene list.