Table 3.
Baseline 24 hour Urine Chemistry
| Placebo | PPI | |||
|---|---|---|---|---|
| HV | UASF | HV | UASF | |
| Total Volume (L/d) | 2.77 ± 0.91 | 2.07 ± 0.67 | 2.69 ± 1.02 | 2.33 ± 0.86 |
| pH | 5.86 ± 0.28 | 5.42 ± 0.36 a | 5.93 ± 0.23 | 5.32 ± 0.36 b |
| Creatinine (gm/d) (mmoles/d) |
1.7 ± 0.6 15.0 ± 5.3 |
1.9 ± 0.5 a 18.8 ± 4.4 |
1.6 ± 0.5 14.2 ± 4.4 |
2.0 ± 0.5 17.7 ± 0.5 |
| Potassium (mEq/d) | 43 ± 13 | 45 ± 12 | 45 ± 14 | 42 ± 13 |
| Sulfate (mEq/d) | 41.2 ± 9.6 | 41.0 ± 9.0 | 39.6 ± 10 | 37.4 ± 12 |
| Phosphate (mg/dl) (mM) |
704 ± 291 22.7 ± 9.4 |
807 ± 304 26.0 ± 9.8 |
683 ± 307 22.0 ± 9.9 |
789 ± 220 22.5 ± 7.1 |
| Ammonium (NH4) (mEq/d) | 39 ± 15 | 32 ± 16 | 39 ± 19 | 33 ± 12 |
| Titratable Acid (mEq/d) | 24 ± 9 | 33 ± 9 c | 25 ± 11 | 34 ± 9 e |
| Citrate (mEq/d) | 9.9 ± 3.7 | 7.3 ± 4.8 d | 9.1 ± 2.2 | 6.2 ± 3.8 b |
| Bicarbonate (mEq/d) Median [range] |
1.1 ± 2.1 0 [0 – 5.6] |
0.3 ± 0.9 0 [0 – 2.72] |
1.6 ± 2.1 0 [0 – 5.9] |
0.4 ± 1.1 b 0 [0 – 3.3] |
| Uric Acid (mg/d) | 657 ± 337 | 540 ± 322 | 570 ± 123 | 472 ± 273 |
| Net Acid Excretion (NAE) (mEq/d) |
53 ± 20 | 58 ± 22 | 53 ± 29 | 60 ± 12 |
| NAE/Sulfate (mEq/mEq) | 0.75 ± 0.07 | 0.55 ± 0.08a | 0.78 ± 0.16 | 0.55 ± 0.15 b |
| NH4/NAE | 0.75 ± 0.07 | 0.55 ± 0.08a | 0.78 ± 0.16 | 0.55 ± 0.15 b |
| Urinary Unmeasured Anions (mEq/d) |
4.5 ± 12.9 | 10.3 ± 8.7 | 7.8 ± 9.9 | 6.9 ± 11.1 |
| Fractional Excretion of Uric Acid (%) |
5.9 ± 2.6 | 4.0 ± 2.6 a | 5.4 ± 2.1 | 3.5 ± 2.0 b |
a
p < 0.05 UASF vs HV; placebo
b
p< 0.05 UASF vs HV; on PPI
c
p = 0.08 UASF vs HV; placebo
d
p = 0.07 UASF vs HV; placebo
e
p = 0.06 UASF vs HV; on PPI
Comparisons made with mixed-model repeated measures analysis.