Table 2.

Inhibition of BoNT/A LC by second generation pyridyl-cinnamyl hydroxamic acids.^a

Compound	R	IC50 (μM)
24		0.23 ± 0.02
25		27.3 ± 7.1
26		35.3 ± 9.6
27		0.56 ± 0.15
28		0.75 ± 0.25
29		0.66 ± 0.19
30		8.01 ± 1.7
31		>100
32		10 ± 1.2
33		0.61 ± 0.12
34		2.79 ± 0.35
35		1.21 ± 0.2
36		73.2 ± 4.2
37		12.3 ± 1.6
38		21.3 ± 5.4
39		1.32 ± 0.27
40		24.9 ± 6.5
41		22.3 ± 8.1
42		1.16 ± 0.38
43		66.2 ± 5.8
44		9.11 ± 0.87

^aIC₅₀ values were determined using the SNAPtide^® assay.¹⁷