Table 1.
Survival analyses after sequential immunotherapy. Mantel-Haenszel analysis demonstrates significant survival differences between groups. CTLA-4 blockade at days 12,15, and 18 alone did not significantly improve survival over control, though there was a trend towards longer survival. Following vaccination with CTLA-4 blockade was significantly better than either modality alone.
| Comparison Group A |
Comparison Group B |
Mantel- Haenszel Survival |
Significance |
|---|---|---|---|
| PBS Vaccination + hamster IgG |
PBS Vaccination + anti-CTLA mAb |
p=.053 | Trend |
| PBS Vaccination + hamster IgG |
GL261-GMCSF vaccination + hamster IgG |
p=.005 | Yes |
| PBS Vaccination + hamster IgG |
GL261-GMCSF vaccination + anti- CTLA-4 mAb |
p=.0008 | Yes |
| PBS Vaccination + anti-CTLA-4 mAb |
GL261-GMCSF vaccination + hamster IgG |
p=.218 | No |
| PBS Vaccination + anti-CTLA-4 mAb |
GL261-GM-CSF vaccination + anti- CTLA-4 mAb |
p=.004 | Yes |
| GL261-GM-CSF vaccination + hamster IgG |
GL261-GM-CSF vaccination + anti- CTLA-4 mAb |
p=.032 | Yes |