Scheme 6.
Reaction of isoquinoline 13 with PIFA. Preparation of compound 17 and proposed mechanism of its formation from 13 via 11a. Reagents and conditions: a) PIFA, CH2Cl2, 0 to 25 °C, 1 h, 11a (11%) plus 17 (7%). TFA = 2,2,2-trifluoroacetic acid.
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