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. Author manuscript; available in PMC: 2013 Jul 5.

Published in final edited form as: Virology. 2012 Apr 19;428(2):86–97. doi: 10.1016/j.virol.2012.03.008

Fig.1 — The engineered FP mutant viruses were tested for VCV sensitivity in a PBMC-based, multi-cycle replication assay. For comparison, the parental, VCV-sensitive clone S, the VCV-resistant clone R and the engineered resistant triple mutant S+a,b,c [previously referred to as S+3FP, (Anastassopoulou et al., 2009)] were also tested in the same experiments. Each experiment was performed on a pool of PBMC from two individuals. For clarity, the dose-response curves are shown in separate panels for (A) single and (B) double FP mutants. The results shown are the average of 7–10 independent experiments each performed using triplicate wells, with the error bars indicating the SEM.

Fig.1 — The engineered FP mutant viruses were tested for VCV sensitivity in a PBMC-based, multi-cycle replication assay. For comparison, the parental, VCV-sensitive clone S, the VCV-resistant clone R and the engineered resistant triple mutant S+a,b,c [previously referred to as S+3FP, (Anastassopoulou et al., 2009)] were also tested in the same experiments. Each experiment was performed on a pool of PBMC from two individuals. For clarity, the dose-response curves are shown in separate panels for (A) single and (B) double FP mutants. The results shown are the average of 7–10 independent experiments each performed using triplicate wells, with the error bars indicating the SEM.