Table 2.
Robustness of p53 dynamics to parameter variations
| Parameter | Scheme 1 |
Scheme 2 |
||||||
|---|---|---|---|---|---|---|---|---|
| −10% |
+10% |
−10% |
+10% |
|||||
| T1% | Lp53% | T1% | Lp53% | T1% | Lp53% | T1% | Lp53% | |
| kdim | 0.1 | 0.0 | −0.1 | 0.0 | −0.3 | 0.0 | 0.3 | 0.0 |
| kacATM | −0.7 | −0.2 | 0.2 | 0.1 | 1.9 | −0.2 | −0.8 | 0.1 |
| kacp530 | −2.6 | −10.0 | 2.5 | 10.0 | 5.2 | −10.0 | −3.8 | 10.0 |
| ksp53 | −7.1 | −10.7 | 7.6 | 10.7 | 17.3 | −10.6 | −8.9 | 10.6 |
| ksmdm2 | 4.3 | 0.0 | −3.3 | 0.0 | −6.0 | 0.0 | 7.3 | 0.0 |
| kmdm2s | −0.4 | 0.8 | 0.5 | −0.9 | −0.5 | 0.7 | 0.5 | −0.7 |
| kmdm2in | 0.8 | 0.7 | −0.7 | −0.7 | −1.5 | 0.6 | 1.3 | −0.6 |
| kacakt | −0.7 | 0.9 | 0.9 | −0.9 | −0.8 | 0.7 | 0.8 | −0.7 |
| kp2 | −1.0 | 0.9 | 1.2 | −1.0 | −1.0 | 0.7 | 1.2 | −0.8 |
| kshzf | −17.1 | 0.1 | 33.6 | −0.1 | −14.7 | 0.1 | 31.0 | −0.1 |
| ksligase | 55.3 | 0.0 | −17.9 | 0.0 | 30.1 | 0.0 | −12.2 | 0.0 |
| ksp21 | −13.2 | 0 | 21.2 | 0 | −9.0 | 0.0 | 12.5 | 0.0 |
| ksce | 52.3 | 0 | −18.5 | 0 | — | — | −26.2 | 0.0 |
| kprb | 20.3 | 0.0 | −11.5 | 0.0 | — | — | −23.1 | 0.0 |
| kasp21e | −4.9 | 0 | 5.1 | 0 | −4.6 | 0.0 | 4.6 | 0.0 |
| ksPTEN | 1.2 | −1.0 | −0.8 | 0.8 | 1.1 | −0.8 | −0.8 | 0.7 |
| ksHIPK2 | −0.6 | 0.0 | 0.7 | 0.0 | 0.8 | 0.0 | −0.6 | 0.0 |
| ksASPP | 0.6 | −0.1 | −0.5 | 0.1 | 0.7 | −0.1 | −0.6 | 0.1 |
For each case, the value of one of 18 parameters is increased or decreased by 10% with respect to the standard parameter set, while nc is set to 20. The bolded values in each column indicate that T1 or Lp53 is more sensitive to variation in the corresponding parameters. The long dash (—) indicates that the cell cannot commit apoptosis in this case.