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. 2012 May 16;102(10):2321–2330. doi: 10.1016/j.bpj.2012.04.008

Figure 1.

Figure 1

Schematic of the target search process by a transcription factor (TF, U-shape) on a rodlike DNA. The TF diffuses in the bulk and may slide one-dimensionally along the DNA while nonspecifically bound. Eventually it reaches its target, the specific binding site placed at z = 0.