Table 2.
GLP-1 and RYGB surgery.
| Author/year | Type of study | Subjects | Preop BMI | % weight loss | F/U time | Change in hormone |
|---|---|---|---|---|---|---|
| Morínigo et al. 2006 [51] | Prospective controlled | 9 (7 F) RYGB non diabetic 6 obese (4 F) |
47.4 ± 6.1 43.6 ± 7.9 |
NA | 6 wk | Greater increase in active GLP-1 postmeal in RYGB group postop compared to weight-matched obese |
| Laferrère et al. 2007 [50] | Prospective controlled | 8F T2DM RYGB 7 non diabetic obese |
43.6 ± 6.8 37.1 ± 11.6 |
NA | 1 mo | Fasting- and glucose-stimulated GLP-1 similar in S and C 1 month after RYGB, increase in GLP-1 (total and active) in response to oral glucose |
| Reinehr et al. 2007 [59] | Prospective controlled | 30 obese (26 F) 19 RYGB 11 GB |
45.7 ± 7.4 | 50% | 2 y | Decrease in fasting GLP-1 in both groups |
| Le Roux et al. 2007 [56] | Double-blind randomized prospective controlled | 7 RYGB 6 AGB |
44.5 ± 2.9 41.9 ± 7.5 |
NA | 9.5 ± 1.5 mo 17 ± 1.4 mo |
Early (2 d) and increased responses of PP GLP-1 in RYGB group only |
| Laferrère et al. 2008 [49] | Prospective controlled | 9 F T2D RYGB 10 F T2D diet induced weight loss |
43.3 ± 6.2 43.3 ± 3.6 |
NA | 1 mo 10 Kg weight loss |
Increase in total GLP-1 after oral glucose and GLP-1 AUC after RYGB but not after diet |
| Peterli et al. 2009 [54] | Randomized prospective controlled | 13 RYGB 14 LSG |
47 ± 6.4 45.7 ± 6.7 |
NA | 1 wk and 3 mo | Increased PP GLP-1 RYGB > LSG |
| Clements et al. 2004 [61] | Prospective uncontrolled | 20 obese (15 F) with T2D | 52.7 ± 8.8 | NA | 2, 6, and 12 wk postop | No change in fasting GLP-1 at any time point |
| Rubino et al. 2004 [60] | Prospective uncontrolled | S: 10 (9 F, 6 T2D) obese RYGB | 46.2 | NA | 3 wk | No change in fasting GLP-1 in postop |
| Borg et al. 2006 [57] | Prospective uncontrolled | 6 RYGB | 48.3 | NA | 1, 3, 6 mo postop | PP GLP-1 AUC increased at 6 mo postop |
| Morínigo et al. 2006 [52] | Prospective uncontrolled | 34 RYGB (23 F, 12 NGT, 12 IGT, 10 T2D) |
49.1 ± 1.0 | NGT: 34.5 ± 1.4 IGT: 29.2 ± 1.9 DM: 32.0 ± 2.4 |
6 wk 12 mo | Increase in PP GLP-1 AUC response in IGT and NGT at 6 wk Increase in PP GLP-1 AUC response in all 3 groups at 12 mo |
| De Carvalho et al. 2009 [53] | Prospective uncontrolled | 11 NGT (9 F) RYGB 8 AGM (4 T2DM, 4 IGT) (7 F) RYGB |
46.1 ± 2.27 46.5 ± 2.04% |
39.3 ± 2.24 36.4 ± 2.6 |
T1: First evaluation T2: presurgery T3: 9 mo after surgery |
Increase in GLP-1 levels after OGTT in both groups at T3 |
| Kashyap et al., 2010 [73] | Prospective uncontrolled | 16 (7 F) T2D 9 RYGB 7 GR |
47 ± 9 | 10% | 4 wk | No change in fasting GLP-1 in both groups Increase in PP GLP-1 response in RYGB group only |
| Le Roux et al. 2006 [55] | Cross-sectional controlled | 6 RYGB 6 GB 12 obese 15 lean |
49.8 46.1 47.1 23.8 |
NA | 6 to 36 mo | Higher postprandial GLP-1 response in RYGB group compared to fasting levels and to other groups |
| Korner et al. 2007 [58] | Cross-sectional controlled | 13 F non diabetic RYGB 10 F BND 13 F OW |
31.3 ± 1.3 36.1 ± 1.7 36.1 ± 2.2 |
35.6 ± 2.4 24.6 ± 2.3 |
24.6 ± 2 mo postop | Fasting GLP-1 similar in all groups At 30 min postmeal, GLP-1 higher in RYGB group compared to BND and OW GLP-1 AUC at 180 min greater in RYBG group compared to other groups |
| Rodieux et al. 2008 [41] | Cross-sectional controlled | 8 RYGB 6 GB 8 weight matched |
44.9 ± 1.8 41.1 ± 0.5 29.2 ± 0.8 |
47.8 ± 3.3 32.4 ± 2.0 |
9 to 48 mo (RYGB) 25 to 85 mo (GB) |
No difference in fasting GLP-1 between 3 groups; Exaggerated GLP-1 PP Response in RYGB. |
Abbreviations: AUC: area under the curve, AGM: abnormal glucose metabolism, BND: adjustable gastric banding, GR: gastric restrictive, IGT: impaired glucose tolerance, LSG: laparoscopic sleeve gastrectomy, NA: data not available, NGT: normal glucose tolerance, OGTT: oral glucose tolerance test, OW: overweight, Postop: postopertaively, PP: postprandial, RYGB: Roux-en-y gastricbBypass, T2D: type 2 diabetes.