Table 3.
GIP and RYGB surgery.
| Author/year | Type of study | Subjects | Preop BMI | % weight loss | F/U time | Change in hormone |
|---|---|---|---|---|---|---|
| Laferrère et al. 2007 [50] | Prospective controlled | 8 F T2D RYGB 7 nondiabetic obese |
43.6 ± 6.8 37.1 ± 11.6 |
NA | 1 mo | Fasting- and glucose-stimulated GIP similar in S and C 1 month after RYGB, increase in GIP in response to oral glucose. |
| Laferrère et al. 2008 [49] | Prospective controlled | 9 F T2D RYGB 10 F T2D diet-induced weight loss |
43.3 ± 6.2 43.3 ± 3.6 |
NA | 1 mo 10 Kg weight loss |
No change in fasting GIP in both groups. Increase in peak GIP after OGTT in RYGB group only. |
| Rubino et al., 2004 [60] | Prospective uncontrolled | 10 (9 F, 6 T2D) obese RYGB | 46.2 | NA | 3 wk | Baseline GIP higher in diabetics compared to nondiabetics. Decrease in fasting GIP in diabetics only. |
| Clements et al. 2004 [61] | Prospective uncontrolled | 20 obese (15 F) with T2D | 52.7 ± 8.8 | NA | 2, 6 and 12 wk postop | Decrease in fasting GIP at 6 and 12 wk. |
| Whitson et al. 2007 [72] | Prospective uncontrolled | 10 (9 F, 5 T2D) RYGB |
50 ± 6 | NA | 6 mo | No change in GIP postop (nonfasting). |
| Kashyap et al. 2010 [73] | Prospective uncontrolled | 16 (7 females) T2D 9 RYGB 7 GR |
47 ± 9 | 10% | 4 wk | No change in fasting or PP GIP in both groups. |
| Korner et al. 2007 [58] | Cross-sectional controlled | 13 F RYGB 10 F BND 13 F overweight |
31.3 ± 1.3 36.1 ± 1.7 36.1 ± 2.2 |
35.6 ± 2.4 24.6 ± 2.3 |
24.6 ± 2 mo postop | Blunted PP GIP peak after RYGB |
Abbreviations: BND: adjustable gastric banding, GR: gastric restrictive, NA: data not available, OGTT: oral glucose tolerance test, Postop: postoperatively, PP: postprandial, RYGB: Roux-en-y gastric bypass, T2D: type 2 diabetes.