Table 1.
Baseline Characteristics (Assessed in the Year Before the Last Menstrual Period Until Gestational Week 10) of 69,448 Pregnancies in Which Women Had Diagnosed Depression, According to Exposure Status, British Columbia Health-Care Utilization Data, 1997–2006
| Characteristic | SSRI Monotherapy (n = 3,169) |
SSRI Polytherapy (n = 333) |
SNRI Monotherapy (n = 408) |
TCA Monotherapy (n = 146) |
No Antidepressant Therapy (n = 65,392) |
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| No. | % | Median (IQR Range) | No. | % | Median (IQR Range) | No. | % | Median (IQR Range) | No. | % | Median (IQR Range) | No. | % | Median (IQR Range) | |
| Delivery year | |||||||||||||||
| 1997–2000 | 743 | 23.5 | 76 | 22.8 | 38 | 9.3 | 71 | 48.6 | 26,595 | 40.7 | |||||
| 2001–2003 | 1,373 | 43.3 | 143 | 42.9 | 154 | 37.8 | 49 | 33.6 | 23,921 | 36.6 | |||||
| 2004–2006 | 1,053 | 33.2 | 114 | 34.2 | 216 | 52.9 | 26 | 17.8 | 14,876 | 22.8 | |||||
| Age, years | 31 (8) | 31 (8) | 30 (7) | 33 (8) | 30 (8) | ||||||||||
| Primiparity | 1,941 | 61.3 | 197 | 59.2 | 252 | 61.8 | 122 | 83.6 | 47,092 | 72.0 | |||||
| Multifetal gestation | 33 | 1.0 | 8 | 2.4 | 7 | 1.7 | 1 | 0.7 | 717 | 1.1 | |||||
| Hypertension (diagnosis and antihypertensives) | 40 | 1.3 | 6 | 1.8 | 4 | 1.0 | 2 | 1.4 | 320 | 0.5 | |||||
| Diabetes | 36 | 1.1 | 9 | 2.7 | 5 | 1.2 | 4 | 2.7 | 472 | 0.7 | |||||
| Obesity | 66 | 2.1 | 14 | 4.2 | 8 | 2.0 | 1 | 0.7 | 1,003 | 1.5 | |||||
| Physician visits, no. | 17 (15) | 26 (24) | 19 (15.5) | 21 (24) | 13 (12) | ||||||||||
| Psychiatrist visits and mental health hospitalizations | |||||||||||||||
| No psychiatric visits and no mental health hospitalizations | 2,395 | 75.6 | 178 | 53.5 | 297 | 72.8 | 107 | 73.3 | 62,870 | 96.1 | |||||
| 1–4 psychiatric visits and no mental health hospitalizations | 394 | 12.4 | 59 | 17.7 | 55 | 13.5 | 16 | 11.0 | 1,376 | 2.1 | |||||
| ≥5 psychiatric visits and no mental health hospitalizations | 232 | 7.3 | 45 | 13.5 | 33 | 8.1 | 18 | 12.3 | 390 | 0.6 | |||||
| ≥1 or more mental health hospitalizations | 148 | 4.7 | 51 | 15.3 | 23 | 5.6 | 5 | 3.4 | 756 | 1.2 | |||||
| Depression claims up to gestational week 20, no. | 4 (5) | 8 (11) | 5 (6) | 3 (5) | 1 (1) | ||||||||||
| Anticonvulsant dispensing | 114 | 3.6 | 39 | 11.7 | 22 | 5.4 | 9 | 6.2 | 462 | 0.7 | |||||
| Antipsychotic dispensing | 118 | 3.7 | 41 | 12.3 | 19 | 4.7 | 8 | 5.5 | 338 | 0.5 | |||||
| Benzodiazepine dispensing | 870 | 27.5 | 165 | 49.6 | 125 | 30.6 | 46 | 31.5 | 4,662 | 7.1 | |||||
| Other mental health disorder | 301 | 9.5 | 71 | 21.3 | 43 | 10.5 | 24 | 16.4 | 2,261 | 3.5 | |||||
| Sleep disorders, migraine, or other pain-related conditions | 263 | 8.3 | 51 | 15.3 | 30 | 7.4 | 20 | 13.7 | 3,893 | 6.0 | |||||
| Total antidepressant days’ supply in the year before the last menstrual period | 240 (234) | 345 (344) | 299 (231.5) | 265.5 (310) | 0 (0) | ||||||||||
| No. of antidepressant classes used in the year before the last menstrual period | |||||||||||||||
| 0 | 403 | 12.7 | 27 | 8.1 | 22 | 5.4 | 27 | 18.5 | 65,392 | 100.0 | |||||
| 1 | 2,435 | 76.8 | 110 | 33.0 | 295 | 72.3 | 96 | 65.8 | 0 | 0 | |||||
| 2 | 294 | 9.3 | 157 | 47.2 | 85 | 20.8 | 19 | 13.0 | 0 | 0 | |||||
| 3–4 | 37 | 1.2 | 39 | 11.7 | 6 | 1.5 | 4 | 2.7 | 0 | 0 | |||||
Abbreviations: IQR, interquartile; SNRI, serotonin-norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant.