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. 2012 Mar 7;12:1. doi: 10.1186/1472-6793-12-1

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Copyright ©2012 Sanders et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hepatic c-myc deletion in c-myc^fl/fl;Alb-Cre expressing mice. A. Schematic representation of the c-myc^flallele showing location of primer pairs used in qPCR analyses to determine the relative abundance of the c-myc^flallele. The graph shows the quantification of the c-myc^flallele in liver from male and female c-myc^fl/fl;Alb-Cre^-/-(open bars), c-myc^fl/fl;Alb-Cre⁺(closed bars) and c-myc^fl/fl;Alb-Cre^+/+(hatched bars) mice as described in the Methods. Data are shown as the mean + 1 SD. *, P < 0.01 c-myc^fl/fl;Alb-Cre⁺versus c-myc^fl/fl;Alb-Cre^-/-. **, P < 0.001 c-myc^fl/fl;Alb-Cre⁺compared to c-myc^fl/fl;Alb-Cre^+/+. B. Hepatic c-myc expression in male and female control and c-myc^fl/fl;Alb-Cre expressing mice as analyzed by RT-qPCR. Data are shown as individual points with the mean. ◊, c-myc^fl/fl;Alb-Cre^-/-; ▲, c-myc^+/+;Alb-Cre; ○, c-myc^fl/fl;Alb-Cre. *, P = 0.001 4 wk c-myc^fl/fl;Alb-Cre vs. controls; **P = 0.0004 8 wk c-myc^fl/fl;Alb-Cre vs. controls; ***P = 0.0028 10 wk c-myc^fl/fl;Alb-Cre vs. controls.