. 2012 Apr 4;13:128. doi: 10.1186/1471-2164-13-128

Table 3.

Ortholog analysis and classifications of the putative TCS proteins

	TCSProtein	RR family	C1	C2	S. mutans UA159	S. mutans NN2025	S. mutans 5 DC8	S. mutans KK21	S. mutans KK23	S.mutans AC4446	S. mutans ATCC 25175	S. mutans NCTC 11060	S.ratti DSM20564	S. sobrinus DSM20742
TCS-1	HK (VicK)	-	HPK1	C	SMU.1516	GI\|290580114	smc\|01510	smd\|01560	sme\|01514	smf\|01497	smg\|01519	smh\|01557	sra\|1000270(90)	sob\|6900029(74)

	RR (VicR)	OmpR	-		SMU.1517	GI\|290580113	smc\|01511	smd\|01561	sme\|01515	smf\|01498	smg\|01520	smh\|01558	sra\|1000269(96)	sob\|6900028(87)

TCS-2	HK (CiaH)	-	HPK1	E	SMU.1128	GI\|290580439	smc\|01121	smd\|01170	sme\|01262	smf\|01137	smg\|01147	smh\|01166	sra\|3300059(83)	sob\|10000005(53)

	RR (CiaR)	OmpR	-		SMU.1129	GI\|290580438	smc\|01122	smd\|01171	sme\|01263	smf\|01138	smg\|01148	smh\|01167	sra\|3300058(94)	sob\|10000006(86)

TCS-3	HK (CovS)	-	HPK1	E	SMU.1145c	GI\|290580424	smc\|01138	smd\|01187	sme\|01279	smf\|01154	smg\|01163	smh\|01183	sra\|3300038(48)	Absent

	RR (CovR)	OmpR	-		SMU.1146c	GI\|290580423	smc\|01139	smd\|01188	sme\|01280	smf\|01155	smg\|01164	smh\|01184	sra\|3300037(76)	Absent

TCS-4	HK (KinF)	-	HPK1	E	SMU.928	GI\|290580625	smc\|00919	smd\|00964	sme\|01045	smf\|00943	smg\|00948	smh\|00938	sra\|1200002(75)	sob\|15200007(50)

	RR (LlrF)	OmpR	-		SMU.927	GI\|290580626	smc\|00918	smd\|00963	sme\|01044	smf\|00942	smg\|00947	smh\|00937	sra\|1200003(89)	sob\|15200008(70)

TCS-5	HK (ScnK)	-	HPK1	E	SMU.1814	GI\|290579846	smc\|01808	smd\|01870	sme\|01810	smf\|01679	Absent	Absent	Absent	Absent

	RR (ScnR)	OmpR	-		SMU.1815	GI\|290579845	smc\|01809	smd\|01871	sme\|01811	smf\|01680	Absent	Absent	Absent	Absent

TCS-6	HK (SpaK)	-	HPK1	E	SMU.660	GI\|290580857	smc\|00645	smd\|00684	sme\|00777	smf\|00640	smg\|00672	smh\|00668	sra\|1000132(71)	sob\|3600002(47)

	RR (SpaR)	OmpR	-		SMU.659	GI\|290580858	smc\|00643	smd\|00682	sme\|00775	smf\|00639	smg\|00670	smh\|00666	sra\|1000130(80)	sob\|3600003(67)

TCS-7	HK (PhoR)	-	HPK1	E	SMU.1037c	GI\|290580522	smc\|01032	smd\|01081	sme\|01153	smf\|01049	smg\|01055	smh\|01052	Absent	Absent

	RR (YcbL)	OmpR	-		SMU.1038c	GI\|290580521	smc\|01033	smd\|01082	sme\|01154	smf\|01050	smg\|01056	smh\|01053	Absent	Absent

TCS-8	HK (KinG)	-	HPK1	M	SMU.1009	GI\|290580539	smc\|01005	smd\|01053	sme\|01135	smf\|01030	smg\|01036	smh\|01024	sra\|900051(80)	sob\|6900007(55)

	RR (LlrG)	OmpR	-		SMU.1008	GI\|290580540	smc\|01004	smd\|01052	sme\|01134	smf\|01029	smg\|01035	smh\|01023	sra\|900049(89)	sob\|6900006(64)

TCS-9	HK (LevS)	-	HPK7	M	SMU.1965c	GI\|290579718	smc\|01957	smd\|02016	sme\|01953	smf\|01824	smg\|01946	smh\|01994	sra\|3500035(88)	Absent

	RR (LevR)	NarL	-		SMU.1964c	GI\|290579719	smc\|01956	smd\|02015	sme\|01952	smf\|01823	smg\|01945	smh\|01993	sra\|3500036(91)	Absent

TCS-10	HK (LytS)	-	HPK8	M	SMU.577	GI\|290580924	smc\|00560	smd\|00598	sme\|00685	smf\|00568	smg\|00588	smh\|00583	sra\|1000030(95)	sob\|800016(80)

	RR (LytT)	LytTR	-		SMU.576	GI\|290580925	smc\|00559	smd\|00597	sme\|00684	smf\|00567	smg\|00587	smh\|00582	sra\|1000029(92)	sob\|800017(70)

TCS-11	HK (LiaS)	-	HPK7	M	SMU.486	GI\|290581011	smc\|00465	smd\|00505	sme\|00595	smf\|00473	smg\|00493	smh\|00475	sra\|2900015(89)	sob\|4200072(64)

	RR (LiaR)	NarL	-		SMU.487	GI\|290581010	smc\|00466	smd\|00506	sme\|00596	smf\|00474	smg\|00494	smh\|00476	sra\|2900013(92)	sob\|4200071(82)

TCS-12	HK (HK11)	-	HPK7	M	SMU.1548c	GI\|290580085	smc\|01542	smd\|01591	sme\|01547	smf\|01527	smg\|01550	smh\|01590	sra\|1000231(53)	sob\|11300005(50)

	RR (RR11)	NarL	-		SMU.1547c	GI\|290580086	smc\|01541	smd\|01590	sme\|01545	smf\|01526	smg\|01548	smh\|01588	sra\|1000232(82)	sob\|11300004(72)

TCS-13	HK(ComD)	-	HPK10	M	SMU.1916	GI\|290579761	smc\|01910	smd\|01968	sme\|01906	smf\|01777	smg\|01900	smh\|01947	Absent	sob\|8500005(37)

	RR (ComE)	LytTR	-		SMU.1917	GI\|290579760	smc\|01911	smd\|01969	sme\|01907	smf\|01778	smg\|01901	smh\|01948	Absent	sob\|8500004(43)

TCS-14	HK	-	?	C	SMU.45	GI\|290579565	smc\|00046	smd\|00053	sme\|00049	Absent	Absent	Absent	Absent	Absent

	RR	?	-		SMU.46	GI\|290579566	smc\|00047	smd\|00054	sme\|00050	Absent	Absent	Absent	Absent	Absent

TCS-15	HK(ComP)	-	HPK7	M	Absent	Absent	Absent	Absent	Absent	Absent	Absent	smh\|00177	Absent	Absent

	RR(CmpR)	NarL	-		Absent	Absent	Absent	Absent	Absent	Absent	Absent	smh\|00178	Absent	Absent

TCS-16	HK		HPK1	E	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent	sra\|800020	Absent

	RR	OmpR			Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent	sra\|800019	Absent

TCS-17	HK		HPK1	E	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent	sra\|3500015	Absent

	RR	OmpR			Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent	sra\|3500014	Absent

TCS-18	HK		HPK11	C	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent	sra\|1400052	Absent

	RR	AmiR			Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent	sra\|1400053	Absent

Orphan HK1	HK		HPK1	N	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent	sra\|3800008	Absent

Orphan HK2	HK		?	M	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent	sob\|13200014

Orphan RR1	RR (GcrR)	OmpR	-		SMU.1924	GI\|290579753	smc\|01920	smd\|01978	sme\|01916	smf\|01787	smg\|01910	smh\|01957	sra\|200007(87)	sob\|100018(55)

Orphan RR2		LytTR			Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent	sob\|14100005