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. 2012 Apr 10;9:66. doi: 10.1186/1742-2094-9-66

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Copyright ©2012 Esposito et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of FK866 on neurotrophins expression. Spinal cord sections were processed at 24 h after SCI to determine the levels for BDNF, GDNF and NT3 by immunohistochemical analysis. A basal level of BDNF (a), GDNF (a1) and NT3 (a2) were detected in the spinal cord from Sham-operated animals, whereas BDNF, GDNF and NT3 levels were substantially reduced in SCI mice (b, b1, b2 respectively). FK866 (c, c1, c2 respectively) treatment prevented the SCI-induced BDNF, GDNF and NT3 reduction. In panel d densitometric analysis is reported. *p < 0.01 vs sham, °p < 0.01 vs SCI + vehicle.