Figure 1.

Relative locations of the 79 genes in the smaller of the two homologues of chromosome 1 in L. major. The thick black line and black circles indicate the DNA and telomeres, respectively. The boxes depict the genes and are color-coded according to the potential functions of their protein products. The “unknown” genes have sequence similarities to genes of unknown function in other organisms. The “novel” genes have no substantive similarities with other sequences in the databases. The 50 contiguous genes on the top strand, including 5 tandem genes encoding long-chain fatty acyl CoA synthetases, are transcribed to the right (→); the 29 contiguous genes on the bottom strand are transcribed to the left (←). The colored vertical lines adjacent to the telomeres indicate telomeric and subtelomeric repeats. The larger of the two chromosome 1 homologues (not shown) has an identical gene organization, but contains an additional 20+ kb of subtelomeric repeats at the right telomere. Adapted from Myler et al. (14).