Table 3.
Cross-sectional cognitive data at last evaluation before death in preclinical AD (pAD) and pathologically normal subjects. Unadjusted and adjusted means with standard errors. Adjusted means account for the effects of age, education, gender, and time from test date to death.
| Instrument | pAD | Normal | p | |||
|---|---|---|---|---|---|---|
| (Mean±SE) | N | (Mean±SE) | N | |||
| CERAD T-Score | Unadj. | 52.5±2.7 | 28 | 57.1±1.3 | 79 | 0.088 |
| Adj. | 54.5±2.5 | 28 | 56.1±1.4 | 75 | 0.596 | |
| MMSE | Unadj. | 27.2±0.5 | 32 | 28.5±0.2 | 88 | 0.019 |
| Adj. | 27.5±0.3 | 32 | 28.3±0.2 | 82 | 0.050 | |
| Logical Memory Imm. | Unadj. | 14.4±0.8 | 28 | 14.9±0.5 | 83 | 0.575 |
| Adj. | 15.0±0.8 | 28 | 14.7±0.5 | 79 | 0.712 | |
| Word List Delayed Recall | Unadj. | 5.6±0.4 | 28 | 6.6±0.2 | 78 | 0.040 |
| Adj. | 6.2±0.4 | 28 | 6.3±0.2 | 74 | 0.887 | |
| Trails A | Unadj. | 52.3±4.6 | 22 | 55.2±3.6 | 78 | 0.629 |
| Adj. | 46.5±6.2 | 22 | 56.0±3.4 | 73 | 0.194 | |
| Word List Total | Unadj. | 18.2±0.8 | 28 | 20.7±0.5 | 79 | 0.013 |
| Adj. | 19.1±0.9 | 28 | 20.3±0.5 | 75 | 0.246 | |
| Verbal Fluency | Unadj. | 13.7±0.8 | 32 | 16.0±0.6 | 87 | 0.034 |
| Adj. | 14.9±0.9 | 32 | 15.5±0.6 | 82 | 0.586 | |
| Constructional Praxis | Unadj. | 8.9±0.2 | 24 | 9.2±0.1 | 72 | 0.262 |
| Adj. | 8.9±0.2 | 24 | 9.2±0.1 | 69 | 0.435 | |