Figure 5.

Dopaminergic dependent interactions with aging on task activity (for both action‐selection and specified conditions). (A) Patients taking dopaminergic medication, compared to control subjects, have an early increase in activity in right inferior frontal cortex, SMA and premotor cortex, thalamus, and right superior cerebellum which decreases with age. In contrast, with healthy aging there is a gradual increase in activity in these regions (P < 0.05 FDR). (B) When “off” medications compared to the “on” state, patients have increasing activity in right superior orbital gyrus, anterior cingulate, insula, thalamus and left temporal cortex, with age (P < 0.05 FDR), whilst when “on” medication activity in these regions declines with age.