Immunohistochemical staining for Popeye domain containing 3 in gastric cancer lesions and noncancerous tissues. A: Popeye domain containing 3 (Popdc3) was highly expressed in noncancerous tissues, × 400; B: Popdc3 was highly expressed in intestinal metaplasia cells, × 400; C, D: Popdc3 was lowly expressed in tubular adenocarcinoma, × 200 and × 400, respectively.