Table 2.

Mortality, weight, food and water intake, liver weight and histology in rats with D-galactosamine-induced acute liver failure with or without SLV338 treatment

	Con	Con+SLV	GalN	GalN+SLV
N	9	9	19	22
Mortality (%)	0	0	42.9	37.1
Weight at injection of GalN (g)	304 ± 7	292 ± 3	300 ± 4	297 ± 3
Weight 48 h after GalN (g)	298 ± 8	298 ± 3	280 ± 6	283 ± 4
Food intake within 48 h after GalN (ml)	47 ± 0.2	49 ± 0.5*	20 ± 1.4***	26 ± 2.0***#
Water intake within 48 h after GalN (ml)	69 ± 1.9	89 ± 2.8***	55 ± 2.4**	65 ± 1.2*##
Liver weight (g)	10.5 ± 0.4	10.6 ± 0.2	9.5 ± 0.5	8.5 ± 0.4*
Liver necrosis score (0-3)	0.61 ± 0.3	0.22 ± 0.1	1.95 ± 0.2**	2.02 ± 0.2**
Liver inflammation score (0-3)	0 ± 0	0 ± 0	0.97 ± 0.2**	1.09 ± 0.2***

Con, controls; SLV, SLV338; GalN, D-galactosamine.

Data are means ± standard error of the mean.

*p < 0.05, **p < 0.01, ***p < 0.001 vs. Con. #p < 0.05, ##p < 0.01 vs. GalN.