Effect of ROS modifiers or vehicle (HPLC water) on Cu2+ (30 μM)-mediated oxidatively generated DNA damage by dopamine (30 μM). Levels of the oxidation DNA products were determined as the mean of 3 to 4 replicates ± SE. Asterick (*) indicates values significantly different from vehicle at P ≤ 0.05. Specific conditions are described in text. Modifiers and target ROS: bathocuproine, Cu(I); methional, Cu(I)OOH and hydroxyl radical; catalase, hydrogen peroxide; SOD and tiron, superoxide; sodium azide and TMP, singlet oxygen; ascorbic acid, mannitol and sodium benzoate, hydroxyl radical and TBP, hydroxyl radical, singlet oxygen and hydroperoxyl radical.