Table 1.
Effect of different formulations of LPSF-PT05 on worm burdens and oogram patterns in experimentally infected mice harbouring adult S. mansoni (BH strain).
| Group | Dosing protocols (mg/Kg × day) | Worm reductions | % egg developmental stages | |||
|---|---|---|---|---|---|---|
| Total worms | Total worms reduction% | Total Immature | Mature | Dead | ||
| Control (7) | 24.60 ± 16.29 | — | 58.88 ± 14.19 | 27.80 ± 10.18 | 13.33 ± 4.40 | |
| LPSF-PT05-Tween (7) | 100 × 5 | 19.43 ± 7.87 | 21.0 | 47.50 ± 7.37 | 27.93 ± 5.49 | 24.58 ± 7.97 |
|
| ||||||
| Control (5) | 30.43 ± 12.20 | 50.72 ± 6.14 | 29.52 ± 4.16 | 19.71 ± 5.51 | ||
| LPSF-PT05-Emulsion (5) | 100 × 5 | 18.25 ± 2.87 | 40.0 | 36.10 ± 12.68 | 31.67 ± 4.35 | 32.23 ± 14.57 |
|
| ||||||
| Control (5) | 26.50 ± 12.34 | 57.51 ± 1.17 | 34.16 ± 3.53 | 8.330 ± 2.36 | ||
| LPSF-PT05-PEG (5) | 100 × 5 | 7.80 ± 3.27 | 70.5# | 35.34 ± 7.05* | 41.41 ± 3.48 | 23.25 ± 5.01# |
| 30 × 5 | 14.00 ± 2.08 | 47.1# | 49.17 ± 6.06 | 24.38 ± 4.87 | 26.46 ± 4.66# | |
| 10 × 5 | 13.80 ± 4.43 | 47.9# | 40.59 ± 15.46 | 33.33 ± 12.02 | 26.10 ± 3.48# | |
| 3 × 5 | 21.25 ± 3.40 | 19.8 | 53.76 ± 5.99 | 28.33 ± 3.60 | 16.66 ± 2.35 | |
The values are expressed in means ± SD. *P ≤ 0.05, # P ≤ 0.01 in comparison to control.
Numbers in brackets represent the numbers of mice.