Table 2.

Brief summary of neutrophil-adenosine receptor literature.

Receptor	System	Stimulus	Manipulation	Effect on Neutrophil	Ref
unspecified	human neutrophil	fMLP	2-chloroadenosine	inhibits adherence to endothelium	29
unspecified	human neutrophil	fMLP	NECA	inhibits neutrophil-mediated endothelial damage	29,44
unspecified	human neutrophil	fMLP	adenosine kinase inhibition	inhibits selectin-based adhesion	47
unspecified	human neutrophil	fMLP	NECA	inhibits oxidative burst	18,73
A1	human neutrophil	fMLP	CPA	promotes chemotaxis	9
A1	human neutrophil	fMLP	CPA	promotes adhesion to gelatin-coated plates	48
A1	porcine neutrophil	PMA	COPA	promotes adhesion	45
A1	human neutrophil	antibody-coated erythrocytes	CPA	promotes FcRγ-mediated phagocytosis	66,67
A1	human neutrophil	FcRγ stimulation	CPA	enhances superoxide production	66
A1, A2A/A2B	human neutrophil	LPS	COPA, CPCA	inhibits TNF release	57
A2	human neutrophil	complement C5, fMLP	NECA	promotes chemotaxis	32
A2	human neutrophil	fMLP	dipyrimidole, NECA	inhibits selectin shedding, expression of β2 integrins	12,49
A2	human neutrophil	fMLP	NECA	inhibits adhesion to fibrinogen-coated plates	48
A2	human neutrophil	antibody-coated yeast	NECA	inhibits FcRγ-mediated phagocytosis	66,67
A2A	porcine neutrophil	PMA	NECA, CGS-21680	inhibits adhesion	45
A2A	canine neutrophil	PAF	CGS-21680	inhibits adhesion	46
A2A	human neutrophil	fMLP, TNF	ATL146e	inhibits adhesion to VCAM-1 coated surface	50
A2A	canine neutrophil	myocardial infarction	ATL146e	inhibits p-selectin expression, infiltration	52
A2A	murine neutrophil	carotid ligation	ATL146e	inhibits recruitment, integrin and selectin expression	53
A2A	human neutrophil	LPS	CGS-21680	inhibits inflammatory chemokine release	58
A2A	Adora2a-/- mice	air pouch inflammation	-	inhibits COX-2 induction	59
A2A	human neutrophil	fMLP	CGS-21680	promotes COX-2, PGE2 generation	59,60
A2A	whole blood, human neutrophil	fMLP	NECA, CGS-21680	inhibits LTB4 synthesis	61,62
A2A	human neutrophil	fMLP	CGS-21680	inhibits leukotriene synthesis	63
A2A	human neutrophil	various	CGS-21680	inhibits LTA4 production	64,65
A2A	rat neutrophil	meningitis	WRC-0470	inhibits degranulation	71
A2A	human, murine, rat neutrophil	fMLP, TNF, PAF, IgG, C3b-zymosan, bacterial meningitis	WRC-0470, CGS-21680, ATL193, ATL146e	inhibits oxidative burst	70,75-79
A2A	human neutrophil	-	CGS-21680	inhibits neutrophil apoptosis	84,85
A2A, A3	human neutrophil	fMLP, TNF, LPS	-	inhibits degranulation	68-70
A2B	murine, human neutrophil	LPS, hypoxia, colitis	netrin-1	inhibits recruitment, transepithelial migration	39-41
A2B	murine neutrophil	fMLP	BAY 60-6583	inhibits superoxide production	83
A3	human neutrophil	fMLP	-	promotes chemotaxis	33
A3	Adora3-/- mice	sepsis	-	inhibits recruitment	34
A3	canine, rabbit neutrophil	PAF	Cl-IB-MECA	inhibits adhesion to endothelium	54

Abbreviations: N-formyl-methionine-leucine-phenylalanine (fMLP), Phorbol myristate acetate (PMA), lipopolysaccharide (LPS), platelet activating factor (PAF), prostaglandin (PG), arachadonic acid (AA), leukotriene (LT), lipoxygenase (LO). See Table 1 for ligand information.