Table 2.
Association of decreased GFR (<60 ml/min per 1.73 m2) by cystatin C and creatinine with adverse events in MESA and CHS
| MESA | CHS | |||||
|---|---|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||||
| n | Demographic Adjusteda |
Fully Adjustedb | n | Demographic Adjusteda |
Fully Adjustedb | |
| All-cause mortalityc | ||||||
| GFR not decreased | 5759 | 1.00 (ref) | 1.00 (ref) | 3639 | 1.00 (ref) | 1.00 (ref) |
| decreased GFRcreat only | 614 | 0.76 (0.48, 1.20) | 0.80 (0.50, 1.26) | 605 | 1.10 (0.98, 1.22) | 1.09 (0.98, 1.21) |
| decreased GFRcys only | 107 | 3.43 (1.96, 5.98) | 3.23 (1.84, 5.67) | 227 | 1.94 (1.67, 2.25) | 1.78 (1.53, 2.08) |
| decreased GFR both | 269 | 1.97 (1.31, 2.96) | 1.93 (1.27, 2.92) | 689 | 1.96 (1.78, 2.16) | 1.74 (1.58, 1.93) |
| Cardiovascular diseased | ||||||
| GFR not decreased | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | ||
| decreased GFRcreat only | 1.18 (0.78, 1.78) | 1.22 (0.80, 1.85) | 1.13 (0.99, 1.29) | 1.05 (0.92, 1.20) | ||
| decreased GFRcys only | 2.22 (1.13, 4.39) | 1.92 (0.97, 3.82) | 1.83 (1.52, 2.21) | 1.52 (1.26, 1.84) | ||
| decreased GFR both | 2.07 (1.32, 3.24) | 1.67 (1.06, 2.63) | 1.86 (1.65, 2.09) | 1.46 (1.29, 1.65) | ||
| Heart failuree | ||||||
| GFR not decreased | 1.00 (ref) | 1.00 (ref) | ||||
| decreased GFRcreat only | 1.08 (0.91, 1.27) | 0.99 (0.84, 1.18) | ||||
| decreased GFRcys only | 2.12 (1.68, 2.66) | 1.69 (1.33, 2.13) | ||||
| decreased GFR both | 1.91 (1.64, 2.23) | 1.43 (1.22, 1.67) | ||||
| Kidney failuref | ||||||
| GFR not decreased | 1.00 (ref) | 1.00 (ref) | ||||
| decreased GFRcreat only | 2.67 (1.03, 6.90) | 2.60 (1.00, 6.75) | ||||
| decreased GFRcys only | 7.69 (2.78, 21.25) | 6.14 (2.18, 17.29) | ||||
| decreased GFR only | 30.95 (17.0, 56.34) | 23.82 (12.68, 44.76) | ||||
ref, referent group.
a
Adjusted for age, race, and gender.
b
Adjusted for age, race, gender, diabetes, hypertension, LDL, HDL, CRP, and prevalent CVD for CHS (persons with baseline CVD were excluded for incident CVD analyses).
c
223 deaths for MESA and 3345 deaths for CHS.
d
212 events for MESA and 2249 events for CHS.
e
1407 events for CHS.
f
84 events for CHS.