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. 2011 Oct 3;21(8):1225–1238. doi: 10.1089/scd.2011.0285

FIG. 1.

FIG. 1.

Nanog exists in gnathostomata but not in Xenopodinae. (A) Phylogenetic tree and verification of Nanog. Species in red letters: Nanog is present. Species in black letters: Nanog is missing. (B) Synteny analysis of human Nanog and its neighboring genes in lower vertebrates created by the Ensembl database (Anolis carolinensis, version 1.0; Xenopus tropicalis, version 4.1). (C) Synteny analysis of fish Nanog and neighboring genes in higher vertebrates. (D) Alignment of the homeodomain (HD) of Nanog from zebrafish, medaka, human, and the HD of Xvent2.1, Nkx2.5, and HoxB6 from X. tropicalis. Amino acids (PAM homology) are shown in red (3 of 6). Percentages of homologies to zebrafish Nanog are given in brackets. D.r., Danio rerio; O.l., Oryzias latipes; H.s., Homo sapiens; X.t., Xenopus tropicalis.