Table 1A.
Biodistribution of 125I-PSA30 Administered Intravenously in Nontumor-Bearing Mice (n=14)
| |
125I-PSA30–%IA/g |
||||
|---|---|---|---|---|---|
| Tissue | 6 hours (n=3) | 24 hours (n=3) | 96 hours (n=3) | 168 hours (n=2) | 312 hours (n=3) |
| Blood | 13.12±12.99 | 2.52±2.26 | 3.76±0.56 | 2.27±0.40 | 1.32±0.61 |
| Spleen | 3.20±2.66 | 0.71±0.78 | 1.03±0.60 | 0.51±0.00 | 0.31±0.17 |
| Lungs | 4.47±3.39 | 0.97±1.05 | 1.20±0.13 | 0.84±0.13 | 0.43±0.19 |
| Kidneys | 4.04±3.18 | 0.69±0.63 | 1.04±0.11 | 0.49±0.23 | 0.28±0.16 |
| Liver | 1.64±1.62 | 0.75±0.79 | 0.85±0.08 | 0.48±0.14 | 0.24±0.12 |
| Bone marrow | 6.21±5.44 | 1.36±1.23 | 2.26±1.78 | 1.28±0.00 | 0.82±0.55 |
| Prostate | 2.34±2.08 | 0.55±0.58 | 0.72±0.16 | 0.66±0.13 | 0.41±0.11 |
| Muscle | 0.46±0.25 | 0.18±0.17 | 0.26±0.04 | 0.15±0.01 | 0.09±0.05 |
| Brain | 0.29±0.22 | 0.07±0.07 | 0.08±0.01 | 0.05±0.01 | 0.03±0.01 |
| Thyroida | 6.0±5.8 | 14±22 | 26±8.0 | 19±3.0 | 25±5.0 |
Mean±standard deviation.
a
Thyroid data presented as % IA per whole organ, not per gram.
PSA, prostate-specific antigen; % IA/g, percentage of injected activity per gram of tissue.