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. Author manuscript; available in PMC: 2013 Apr 11.
Published in final edited form as: J Am Chem Soc. 2012 Mar 29;134(14):6218–6223. doi: 10.1021/ja2106477

Figure 1.

Figure 1

Depiction of forces that govern the interaction of a lipid– oligonucleotide conjugate (LO) with mammalian cells. The hydrophobic effect mediated by the lipid tails stabilizes an LO in a cellular membrane, enabling analysis of the consequences of Coulombic repulsion between an anionic nucleic acid and anionic sialic acid and glycosaminoglycans (GAGs).