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Effect of TRPV4 inhibitors on flow-induced dilation of coronary arterioles. Incubation of coronary arterioles with the TRPV4 inhibitors RuR (1 μM; A), gadolinium III (100 μM; B), or RN-1734 (20 μM; C) attenuated dilatory responses to flow. RN-1734 (20 μM; D) had no significant effect on bradykinin-induced dilation. Luminal flow was generated by pressure gradients of 10–100 cmH2O (A and B) or of 20–100 cmH2O (C). n = 6 (A), 4 (B), 4 (C), and 4 (D). *P < 0.05 vs. control.
