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Constitutive overexpression of S68E mutant results in early mortality and cardiac hypertrophy. Top: survival curve of WT (n = 20) and mice constitutively overexpressing S68E mutant (conS68E; n = 15). Bottom: hearts (n = 3 each for WT and conS68E mice) from 6-wk-old mice were sectioned and stained with Masson trichrome. Representative images from WT (left) and conS68E (right) hearts are shown.
