Table 1.

Echocardiographic parameters of constitutively overexpressed PLM S68E mice

	Wild-type	ConS68E
4 wk
Body weight, g	18.8 ± 0.6 (14)	15.6 ± 0.8* (12)
LV mass, mg	44.5 ± 2.2	53.6 ± 3.8+
Heart rate, beats/min	429 ± 12	204 ± 22*
Ejection fraction, %	76.1 ± 1.5	89.5 ± 2.3*
Fractional shortening, %	44.1 ± 1.4	61.1 ± 2.8*
Stroke volume, μl	34.2 ± 1.6	51.4 ± 4.2*
Cardiac output, ml/min	14.6 ± 0.7	10.3 ± 1.0*
22 wk
Body weight, g	25.5 ± 0.5 (14)	27.0 ± 1.2 (7)
LV mass, mg	72.8 ± 2.2	92.8 ± 6.9*
Heart rate, beats/min	458 ± 13	301 ± 38*
Ejection fraction, %	71.9 ± 1.5	74.2 ± 2.6
Fractional shortening, %	40.6 ± 1.3	43.1 ± 2.2
Stroke volume, μl	40.9 ± 1.8	57.0 ± 4.5*
Cardiac output, ml/min	18.5 ± 0.7	17.2 ± 2.4

Values are means ± SE for number of mice in parentheses. PLM, phospholemman; conS68E, transgenic mice constitutively overexpressing PLM S68E mutant; LV, left ventricle.

^*P < 0.005; ⁺P < 0.05; wild-type vs. conS68E.