Fig. 4.
Average [Ca2+]mito (A) and simultaneously recorded developed LVP (B) from young and old hearts before, during, and after ischemia-reperfusion (I/R) injury. Old hearts exhibited less [Ca2+]mito loading during ischemia than young hearts. Old hearts also exhibited less [Ca2+]mito loading after 60 min REP compared with young hearts. Before ischemia, no differences were observed in developed LVP between old and young hearts. However, throughout REP, developed LVP in young hearts was lower than that observed in old hearts.