Fig. 3.

Daily mRNA expression profiles of clock and target genes in hearts isolated from diabetic db/db mice and control mice. Hearts were isolated from 9- to 10-wk-old male db/db mice (● and dashed lines) and control mice (○ and solid lines), and the mRNAs of specific genes were quantified using real-time PCR. A: CLOCK. B: BMAL1. C: Per1. D: Per2. E: Cry1. F: Cry2. G: Rev-erb-α. H: DBP. I: PPAR-γ. ***P < 0.001 when compared between db/db mice and control mice at the same time point in the post hoc analysis.