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The diurnal variation of the contractile response to phenylephrine (PE) is altered in db/db compared with control mouse abdominal aorta strips. Male 9- to 10-wk-old control mice (A–C) and db/db mice (D–F) were euthanized at ZT5, ZT11, ZT17, and ZT23. Isometric contractions in response to cumulative does of PE were determined in endothelium-denuded abdominal aortic helical strips. **P < 0.01 compared with the corresponding ZT5 point in the post hoc analysis.
