Fig. 7.

Diurnal variations of maximal contractile responses to high K⁺ and ANG II are altered in db/db compared with control mouse abdominal aorta strips. Male 9- to 10-wk-old control mice (A and B) and db/db mice (C and D) were euthanized at ZT5, ZT11, ZT17, and ZT23. Isometric contractions in response to maximal does of high K⁺ depolarization (143 mM; A and C) or ANG II (100 nM; B and D) were determined in endothelium-denuded abdominal aortic helical strips. n = 8–9 for each time point. *P < 0.05 compared with the corresponding ZT5 point in the post hoc analysis.