Fig. 8.

Diurnal variations of in vivo pressor responses to intravenous PE and ANG II injection were lost in db/db mice. Male 10-wk-old control mice and db/db mice were instrumented with radiotelemetry, recovered for 10 days, and underwent basal blood pressure collection for 3 days. Mice were then anesthetized with isoflurane, and various doses of PE or ANG II were injected via a femoral vein. A and B: representative original blood pressure recordings. C–F: quantification of maximal net blood pressure increases in response to PE and ANG II injections. MAP, mean arterial pressure; ns, not significant. n = 3–6. *P < 0.05. **P < 0.01.