Table 1.

Biometric and echocardiographic parameters of WT and AMPK KD mice challenged with ethanol (3 g/kg, ip for 3 days)

Parameter	WT	WT-EtOH	KD	KD-EtOH
Body weight (g)	24.2 ± 0.6	22.0 ± 1.0	24.2 ± 0.8	22.2 ± 0.9
Heart weight (mg)	126 ± 8	116 ± 4	116 ± 4	115 ± 4
Heart/body weight (mg/g)	5.18 ± 0.26	5.44 ± 0.16	4.83 ± 0.16	5.23 ± 0.15
Liver weight (g)	1.20 ± 0.06	1.06 ± 0.03	1.24 ± 0.06	1.18 ± 0.06
Liver/body weight (mg/g)	49.2 ± 1.8	48.3 ± 1.5	51.5 ± 0.8	53.1 ± 2.3
Kidney weight (g)	0.28 ± 0.01	0.27 ± 0.01	0.30 ± 0.01	0.30 ± 0.01
Kidney/body weight (mg/g)	11.6 ± 0.4	12.7 ± 0.2	12.6 ± 0.3	13.5 ± 0.4
Blood alcohol (mg/dL)	Undetectable	70.1 ± 7.1*	Undetectable	73.6 ± 8.1*
Diastolic blood pressure (mmHg)	79.0 ± 1.4	74.4 ± 0.8	79.3 ± 1.5	74.5 ± 0.8
Systolic blood pressure (mmHg)	106.9 ± 2.4	101.9 ± 2.3	105.5 ± 2.6	99.4 ± 1.2
Heart rate (b.p.m.)	493 ± 13	505 ± 24	497 ± 13	500 ± 24
Diastolic wall thickness (mm)	0.96 ± 0.03	0.94 ± 0.03	0.97 ± 0.03	0.89 ± 0.08
LV ESD (mm)	1.32 ± 0.07	1.42 ± 0.11	1.25 ± 0.06	1.07 ± 0.06#
LV EDD (mm)	2.65 ± 0.13	2.28 ± 0.13*	2.58 ± 0.12	2.18 ± 0.09*
Fractional shortening (%)	50.3 ± 1.1	42.3 ± 1.8*	51.4 ± 0.8	50.9 ± 1.8#
Ejection fraction (%)	87.5 ± 0.9	80.0 ± 1.9*	88.5 ± 0.7	87.7 ± 1.5#

LV ESD, left ventricular end-systolic diameter; LV EDD, left ventricular end-diastolic diameter; Mean ± SEM, n = 10–14 mice/group.

*P < 0.05 vs. WT group.

^#P < 0.05 vs. WT-EtOH group.