Table 3.

Mean levels of dopamine utilization, dopamine and respective metabolites (DOPAC and HVA) measured ex vivo in the caudate, putamen, nucleus accumbens core, and nucleus accumbens shell of saline- and methamphetamine-exposed monkeys

	Caudate		Putamen		Nucleus accumbens core		Nucleus accumbens shell
	SAL	MA	SAL	MA	SAL	MA	SAL	MA
DOPAC/DA	0.08 ± 0.01	0.11 ± 0.02	0.07 ± 0.01	0.12 ± 0.02**	0.14 ± 0.01	0.19 ± 0.02**	0.22 ± 0.02	0.25 ± 0.02
HVA/DA	0.82 ± 0.09	1.46 ± 0.23*	0.99 ± 0.15	1.54 ± 0.17*	1.44 ± 0.17	2.29 ± 0.34**	1.56 ± 0.18	1.83 ± 0.24
DA	87.69 ± 20.98	41.66 ± 8.86	110.15 ± 18.09	59.34 ± 4.30**	77.02 ± 10	42.37 ± 2.87***	64.79 ± 13.1	46.65 ± 6.35
DOPAC	6.77 ± 4.11	4.85 ± 3.15	7.22 ± 1.80	7.21 ± 1.22	11.41 ± 2.11	8.29 ± 0.76	14.24 ± 5.42	11.92 ± 3.94
HVA	72.09 ± 16.28	60.71 ± 16.04***	103.20 ± 16.25	91.34 ± 11.86	110.39 ± 18.08	97.28 ± 14.63	99.88 ± 30.2	85.56 ± 33.1

Mean levels are ng/mg tissue ± SEM. Dopamine utilization, the ratio of levels of the metabolite to levels of dopamine; DA, dopamine; SAL, saline; MA, methamphetamine. Significant group differences are highlighted in bold.

*p < 0.05;

**p < 0.01;

***p < 0.001.