Table 2.
Association of Age, Sex, and Race with Carotid Artery Distensibility Coefficient and Diameter
|
Difference in DC (2*slope) mm Hg−1 |
% Larger carotid diameter (intercept) |
---|---|---|
Covariate | Beta coefficients (95% CI) | |
Sex (male vs. female) at 65 years of age | 8.24 (0.62-15.8)×10−5 | 4.83 (3.99-5.69)% |
Age (difference per year among females) | −5.04 (−5.38-−4.70)×10−5 | 0.24 (0.20-0.28)% |
Difference in age-associated slope between men and women | 7.14 (2.10-12.2)×10−6 | −0.10 (−0.15-−0.04)% |
Height (difference per cm of height) | 3.08 (−0.98-7.14)×10−6 | 0.19 (0.15-0.24)% |
White | Reference | Reference |
Chinese vs. White | −1.88 (−2.81-−0.96)×10−4 | −3.77 (−2.78-−4.75)% |
African American vs. White | −3.06 (−3.70-−2.42)×10−4 | −0.09 (−0.81-0.62)% |
Hispanic vs. White | −2.81 (−3.55-−2.07)×10−4 | 1.15 (0.33-1.97)% |
Overall test for race/ethnicity | p=7.6×10−23 | p=1.1×10−13 |
Intercept: mixed model intercept coefficient corresponding to group difference between geometric means in percent; slope: mixed model slope coefficient corresponding to distensibility coefficient difference by group; 2*slope=difference in distensibility coefficient; to allow for judging of magnitude of coefficients, the standard deviation (SD) of distensibility coefficient=1.1×10−3; for example, the beta coefficient for age in women is −5.04×10−5/mm Hg. This means that, on average, keeping other covariates constant, if 2 women differ 1 year in age, the older would have DC lower by −5.04×10−5/mm Hg, which corresponds to 0.045 SD units. The SI unit for distensibility, kPa−1=7.5 mm Hg−1.