Figure 1. Human interaction network shows high connectivity among putative human toxicity-modulating proteins homologous to toxicity-modulating proteins in yeast.

The largest connected component of the human interactome selected from yeast orthologs being required for damage recovery after treatment with MMS, 4NQO, t-BuOOH and UV [13]. The circles represent: red – proteins with toxicity-modulating yeast homologs targeted for silencing in this study; grey – proteins with toxicity-modulating yeast homologs not targeted in this study; blue – proteins with non-toxicity-modulating yeast homologs targeted in this study; green –proteins specific for mammalian telomere maintenance targeted in this study. An interactive version of this figure is available at http://www.bionut.ki.se/users/pesv/MIT/fig1.html.