Table 2. Pathway Association Results.

		Hypertension		DBP		SBP
Pathway	SNPs	N Sig	Ppath	N Sig	Ppath	N Sig	Ppath
ADRA1	618	40	0.0009*	34	0.0007*	37	0.06
ADRA1, – receptors†	588	27	0.03	20	0.01	24	0.52
ADRA2	668	22	0.01	27	0.06	27	0.06
ADRB2	631	22	0.03	29	0.13	28	0.21
ADRB1	610	20	0.04	26	0.09	26	0.20
ET	415	26	0.08	18	0.23	20	0.91
DRD1A	825	42	0.09	40	0.004	47	0.76
AVP1	284	19	0.10	12	0.06	14	0.89
VIP	316	11	0.12	18	0.37	13	0.29
KATP	20	1	0.14	1	0.20	1	0.31
DRD1B	430	13	0.15	23	0.22	23	0.40
ACH	380	13	0.18	23	0.35	16	0.17
AVP2	89	1	0.18	5	0.57	6	0.25
RAA1	312	21	0.20	22	0.58	16	0.41
RAA2	363	26	0.22	26	0.55	19	0.47
PGI2	296	12	0.23	17	0.31	13	0.29
AT2C	965	49	0.23	45	0.73	46	0.85
PUR2	89	4	0.24	1	0.77	4	0.84
NA	807	33	0.25	41	0.68	42	0.71
HIST	325	14	0.27	19	0.25	16	0.12
NAK	444	38	0.28	32	0.19	28	0.11
PUR1	72	2	0.40	2	0.14	1	0.71
PX	72	4	0.45	6	0.16	4	0.05
NO	591	26	0.48	29	0.51	31	0.59
ANP	21	1	0.50	0	1.00	1	0.38
AT2A	144	9	0.51	11	0.37	8	0.15
BNP	20	1	0.52	0	1.00	1	0.40
AT2B	235	12	0.64	20	0.46	13	0.24
CNP	21	0	1.00	1	0.28	0	1.00

^*p-value is significant after correction for multiple testing.

^†ADRA1, -receptors is the same pathway as ADRA1, with the ADRA1 receptor genes removed from the model.

Adjustment was made for sex, age, age² and BMI for all models.