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. 2012 May 16;7(5):e37381. doi: 10.1371/journal.pone.0037381

Figure 5. Inflammatory cytokines in CVLs after treatment of SFT gel and other microbicide candidates.

Figure 5

Inflammatory cytokines, including IL-6 (a), TNF-α (b), IFN-γ (c), IL-10 (d) and IL-17A (e), were quantified in CVLs collected at 12 h post final dosage in the context of 3 consecutive days of intravaginal application of placebo (1.5% HEC), 0.03 mM SFT gel, 0.3 mM SFT gel, 3 mM SFT gel, 3% carrageenan gel, 1% TFV gel, 6% CS gel and 1% N-9 gel, respectively. The X-axis indicated the administration of different microbicide candidates; the Y-axis indicated the production of corresponding inflammatory cytokines. Data represent means ± SD from 5 mice per group. Student's t-test was performed to determine the significance of difference between the placebo gel control group and the treatment group for each microbicide candidate, *p<0.05.