Table 2. Association of uric acid values with i-IFG, i-IGT, IFG/IGT, NDD, and known diabetes (comparisons with NGT), KORA F4 study.
| i-IFG | i-IGT | IFG/IGT | NDD | Known diabetes | |
| Total sample | (n = 113) | (n = 315) | (n = 69) | (n = 108) | (n = 230) |
| Men | (n = 75) | (n = 147) | (n = 42) | (n = 61) | (n = 135) |
| Women | (n = 38) | (n = 168) | (n = 27) | (n = 47) | (n = 95) |
| † Model 1: OR (95%-CI) | |||||
| Total sample | 1.66 (1.43–1.92) | 1.26 (1.14–1.40) | 1.57 (1.31–1.89) | 1.57 (1.35–1.83) | 1.55 (1.38–1.73) |
| Men | 1.59 (1.33–1.90) | 1.24 (1.08–1.43) | 1.35 (1.06–1.71) | 1.20 (0.98–1.47) | 1.29 (1.11–1.50) |
| Women | 1.77 (1.36–2.31) | 1.31 (1.12–1.54) | 1.99 (1.49–2.67) | 2.24 (1.79–2.80) | 2.07 (1.73–2.48) |
| ‡ Model 2: OR (95%-CI) | |||||
| Total sample | 1.73 (1.47–2.03) | 1.25 (1.12–1.40) | 1.49 (1.22–1.83) | 1.45 (1.23–1.71) | 1.40 (1.24–1.59) |
| Men | 1.67 (1.37–2.04) | 2.21 (1.04–1.41) | 1.26 (0.97–1.63) | 1.09 (0.88–1.36) | 1.19 (1.02–1.40) |
| Women | 1.90 (1.41–2.55) | 1.32 (1.12–1.57) | 1.95 (1.40–2.72) | 2.11 (1.63–2.72) | 1.86 (1.52–2.28) |
| § Model 3: OR (95%-CI) | |||||
| Total sample | 1.61 (1.37–1.91) | 1.20 (1.07–1.34) | 1.33 (1.09–1.64) | 1.30 (1.09–1.53) | 1.30 (1.15–1.48) |
| Men | 1.59 (1.29–1.96) | 1.17 (1.00–1.37) | 1.15 (0.88–1.50) | 0.99 (0.79–1.24) | 1.12 (0.95–1.32) |
| Women | 1.71 (1.25–2.32) | 1.25 (1.05–1.49) | 1.69 (1.20–2.39) | 1.84 (1.41–2.39) | 1.69 (1.37–2.09) |
| ||Model 4: OR (95%-CI) | |||||
| Total sample | 1.50 (1.26–1.77) | 1.10 (0.98–1.24) | 1.22 (0.98–1.50) | 1.18 (1.00–1.40) | 1.17 (1.03–1.34) |
| Men | 1.49 (1.21–1.84) | 1.09 (0.93–1.28) | 1.06 (0.81–1.39) | 0.91 (0.72–1.14) | 1.04 (0.88–1.23) |
| Women | 1.57 (1.15–2.14) | 1.14 (0.95–1.36) | 1.52 (1.07–2.16) | 1.67 (1.28–2.17) | 1.47 (1.18–1.82) |
| P-value for uric acid*sex interaction (Total sample) | 0.8027 | 0.7449 | 0.0720 | 0.0007 | 0.0172 |
Odds ratio (OR) expressed per mg/dL increment in uric acid concentration; if the confidence intervals around the odds ratios overlap, then the odds ratios are not significantly different
†
Model 1: adjusted for age and sex (only total sample).
‡
Model 2: adjusted for age, sex, actual hypertension, regular smoking, physical activity, alcohol intake, and creatinine.
§
Model 3: adjusted for age, sex, actual hypertension, regular smoking, physical activity, alcohol intake, creatinine, total cholesterol, and HDL cholesterol.
||
Model 4: adjusted for age, sex, actual hypertension, regular smoking, physical activity, alcohol intake, creatinine, total cholesterol, HDL cholesterol, and BMI.