Table 1. Significant estimated interaction coefficients from Poisson regression of the primary screen results and the corresponding P values.
| Gene Symbol | Interaction Coefficient | P value | Adjusted P value1 |
| IL28RA 2 | −2.4228 | 0 | 0 |
| RIG-I | −2.1559 | 0 | 0 |
| IRF2 | −2.1088 | 0 | 0 |
| IRF1 | −0.8664 | 0 | 0 |
| PSMB9 | −0.733 | 0 | 0 |
| C5orf39 | −0.6977 | 0 | 0 |
| IRF7 | −0.6034 | 0 | 0 |
| SSBP3 | −0.5504 | 0 | 0 |
| SAMD4A | −0.4467 | 0 | 0 |
| CXCL9 | −0.4015 | 0 | 0 |
| MDA5 | −0.3381 | 0 | 0 |
| IFITM3 | −0.3163 | 0 | 0 |
| MAB21L2 | −0.3131 | 0 | 0 |
| MYD88 | −0.2517 | 0 | 0 |
| HPSE | −0.2507 | 0 | 0 |
| COMMD3 | −0.2358 | 0 | 0 |
| S100A8 | −0.2357 | 0 | 0 |
| UPP2 | −0.2207 | 0 | 0 |
| SMAD3 | −0.2169 | 0 | 0 |
| GBP2 | −0.2151 | 0 | 0 |
| MKX | −0.2128 | 0 | 0 |
| IFIT5 | −0.201 | 0 | 0 |
| SAMHD1 | −0.1927 | 0 | 0 |
| BTN3A3 | −0.1764 | 0 | 0 |
| RASSF4 | −0.1761 | 0 | 0 |
| SNN | −0.1592 | 0 | 0 |
| PHF11 | −0.1537 | 0 | 0 |
| FLJ39739 | −0.1469 | 0 | 0 |
| KIAA0040 | −0.1324 | 0 | 0 |
| IFI44L | −0.123 | 0 | 0 |
| STAT3 | −0.1212 | 0 | 0 |
| TAGAP | −0.1212 | 0 | 0 |
| LINCR | −0.119 | 0 | 0 |
| PCTK2 | −0.1172 | 0 | 0 |
| GTPBP2 | −0.1147 | 0 | 0 |
| FAM70A | −0.1126 | 0 | 0 |
| DEFB1 | −0.1118 | 0 | 0 |
| EPSTI1 | −0.1116 | 0 | 0 |
| LMO2 | −0.1108 | 0 | 0 |
| GEM | −0.1033 | 0 | 0 |
| C4orf33 | −0.0992 | 0 | 0 |
| GTPBP1 | −0.0979 | 0 | 0 |
| DDIT4 | −0.0951 | 0 | 0 |
| ANKRD22 | −0.0943 | 0 | 0 |
| FBXO6 | −0.0939 | 0 | 0 |
| MT1X | −0.0925 | 0 | 0 |
| PMAIP1 | −0.0906 | 1.00E−04 | 1.00E−04 |
| ETV7 | −0.09 | 1.00E−04 | 2.00E−04 |
| ABTB2 | −0.0885 | 1.00E−04 | 3.00E−04 |
| SOCS2 | −0.085 | 1.00E−04 | 1.00E−04 |
| ADFP | −0.0818 | 3.00E−04 | 6.00E−04 |
| UBE2L6 | −0.0762 | 3.00E−04 | 6.00E−04 |
| LAMP3 | −0.0747 | 2.00E−04 | 4.00E−04 |
| ARG2 | −0.0734 | 3.00E−04 | 6.00E−04 |
| LRG1 | −0.07 | 3.00E−04 | 6.00E−04 |
| VAMP5 | −0.066 | 0.0037 | 0.0058 |
| CCDC109B | −0.0657 | 0.0016 | 0.0028 |
| CXCL10 | −0.0656 | 0.0023 | 0.0037 |
| GCH1 | −0.0642 | 9.00E−04 | 0.0016 |
| GBP5 | −0.0629 | 0.0032 | 0.0052 |
| PRIC285 | −0.0613 | 0.003 | 0.0049 |
| ADAMDEC1 | −0.0583 | 0.0046 | 0.0071 |
| PDK1 | −0.0582 | 0.0092 | 0.0135 |
| CMAH | −0.0531 | 0.0069 | 0.0102 |
| ANGPTL1 | −0.0477 | 0.0232 | 0.0322 |
| CCDC75 | −0.0455 | 0.0175 | 0.0247 |
| ERLIN1 | −0.0451 | 0.0271 | 0.0374 |
| DHX58 | −0.0449 | 0.0323 | 0.0436 |
| BATF2 | −0.0448 | 0.0303 | 0.0415 |
1
The P values were adjusted using the BH procedure to adjust for multiple comparisons.
2
ISGs listed in bold demonstrated the largest reduction in percentage of infected cells upon coexpression of ZAP and were chosen for the initial follow up confirmatory testing.