Table 2.
Adjusted* Odds Ratios (95% Confidence Interval (CI)) Relating Depressive Symptoms / Antidepressant Use to Incident Frailty at 3 Years Follow-Up
| Not Frail (n= 14874) | Intermediate Frailty (n=8653) | Frail (n= 4125) | ||||
|---|---|---|---|---|---|---|
| n | n | Odds Ratio (95% CI) | n | Odds Ratio (95% CI) | p-value | |
| Not depressive | ||||||
| Antidepressant non-user | 13808 | 7547 | 1.00 | 3403 | 1.00 | <0.001 |
| Antidepressant user | 446 | 396 | 1.49 (1.27-1.76) | 258 | 1.79 (1.47-2.19) | |
| Depressive | ||||||
| Antidepressant non-user | 555 | 610 | 1.75 (1.52-2.03) | 379 | 2.11 (1.77-2.52) | |
| Antidepressant user | 65 | 100 | 2.28 (1.56-3.32) | 85 | 3.64 (2.41-5.53) | |
*
Adjusted for age, income, education, race, living alone, body mass index (BMI), self-reported health, ADL disability, smoking, alcohol consumption, hormone therapy use, hypertension, diabetes, hx coronary heart disease (CHD), hx chronic obstructive pulmonary disease (COPD), hx hip fracture at age >=55, at least 2 falls in previous year, history arthritis, history cancer, history stroke, and presence of at least 2 chronic diseases.
CI = Confidence Interval, OR = Odds Ratio