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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: J Neuroimmune Pharmacol. 2011 Dec 27;7(2):454–464. doi: 10.1007/s11481-011-9332-1

Fig. 1.

Fig. 1

DA levels in the striatum were lower in late stage SIV infection. Macaques were mock inoculated (SIV-) or inoculated with SIV, then euthanized at various days postinoculation (dpi). Levels of DA (a), DOPAC (b), and HVA (c) in the striatum were determined using HPLC with EC detection and ratios of DOPAC/DA (d) and HVA/DA (e) were calculated. Amounts are expressed as ng neurotransmitter or metabolite per mg of tissue. Levels of DA and its metabolite DOPAC were significantly lower in late stage SIV infection (p=0.002 and p= 0.031, respectively). Levels of the metabolite HVA were not significantly lower in SIV infection (p=0.112). The ratio of DOPAC/DA was not significantly different in SIV infection (p=0.160), but the ratio of HVA/DA was significantly higher in late SIV infection (p=0.017). Bars represent medians. Statistical comparisons were made using the Mann–Whitney test