Table 1. Blood COHb levels following interpertional administration of CORM-A1 in mice.

Blood COHb levels were measured by absorbance at 420 and 432nm. Percentage COHb was calculated from the A₄₂₀/A₄₃₂ ratio using previously published molar absorptivities of mouse hemoglobin, F₁=1.301, F₂=0.464, F₃=2.053 [79]. CORM-A1 when administered at a concentration of 7.5 mg/kg resulted in a significant increase in blood COHb levels for up to 45 min post administration, n=6/group. * = P <0.05 as compared to baseline, iCORM-A1=inactive CORM-A1.

CORM-A1 Concentration	Blood COHb (Percentage of baseline)
	Time Post Administration (min)
	15	30	45	60	120
7.5mg/kg	147±10*	134±1*	118±1*	108±2	105±8
5mg/kg	105±11	112±8	94±5	90±4	94±5
3mg/kg	107±3	105±8	88±6	93±15	89±4
1.5mg/kg	105±12	102±7	100±10	100±3	100±2
iCORM-A1 (7.5 mg/kg)	101±10	93±7	93±9	90±2	100±8