. Author manuscript; available in PMC: 2013 Jun 1.

Published in final edited form as: Ther Drug Monit. 2012 Jun;34(3):312–319. doi: 10.1097/FTD.0b013e3182587665

TABLE 3.

Final Population Pharmacokinetic Model Parameter Estimates

Parameter	Symbol	Point Estimate	%RSE	Bootstrap CI
Parameter	Symbol	Point Estimate	%RSE	2.5%	Median	97.5%
CL (L/h/kg^0.75)	θ_CL	0.479	13.7	0.352	0.466	0.606
V (L/kg)	θ_v	2.91	30.8	1.640	2.935	5.615
Inter-individual Variance
CL (CV%)	ω²_CL	91.54	19.5	83.86	94.88	103.87
V (CV%)	ω²_V	119.16	32.2	88.39	108.54	124.14
CL vs. V correlation	ω²_CL-V	101.5	21.5	94	98	100
Residual Variance (CV%)	σ²	73.82	13.7	79.25	85.56	91.27

CL, clearance; V, volume of distribution; CV, coefficient of variation; CI, confidence interval; RSE, relative standard error.