TABLE 4.

Individual Empirical Bayesian Pharmacokinetic Parameter Estimates by Gestational Age Group

Gestational Age (Weeks)	CL (L/h)	95% CI	CL (L/h/kg)	95% CI	V (L)	95% CI	V (L/kg)	95% CI	Half-life (h)	95% CI
<26	0.239	0.048, 1.286	0.311	0.069, 1.303	2.15	0.32, 16.99	3.44	0.51, 20.91	8.8	2.7, 16.8
26–29	0.401	0.037, 1.306	0.371	0.055, 0.777	2.44	0.40, 10.09	2.83	0.39, 9.21	5.9	1.5, 17.4
30–32	0.393	0.248, 1.612	0.261	0.145, 1.671	3.38	1.47, 17.98	2.42	0.86, 13.25	4.5	1.6, 7.7
Overall	0.302	0.044, 1.612	0.338	0.067, 1.303	2.75	0.32, 16.99	2.72	0.48, 17.16	6.9	1.7, 16.7

CL, clearance, V, volume of distribution; CI, confidence interval.