Figure 6.
Normal H2O2-induced apoptosis in ADF/cofilin-deficient MEFs. (a) Translocation of n-cofilin and ADF to the mitochondrial fraction during H2O2-induced apoptosis. Induction of apoptosis was confirmed by the translocation of cytochrome c to the cytosol. (b) H2O2-induced apoptosis at different time points (0–4 h) was scored according to chromatin condensation and nucleus morphology. Unaltered apoptosis rates were found in n-Cof−/−, ADF−/−, or AC-MEFs (quantified from six independent experiments)